The Detroit Lions (2-1) visit Bank of America Stadium to face the Carolina Panthers (1-2) in a Week 4 NFC matchup scheduled for October 4, 2026 at 8:20 PM EDT on NBC. DraftKings lists Detroit as a 3.5-point favorite with an over/under of 51.5 points, setting the stage for a game where the Lions look to build on their early-season momentum while the Panthers aim to avoid falling further behind in the division.
Carolina will be looking to snap a two-game skid at home, where they'll need to solve a Detroit defense that has helped the Lions post a winning record through three weeks. The Panthers' offense will need to find consistency against a Lions team that has shown resilience on the road, with the outcome likely determining which squad gains ground in what's shaping up to be a competitive NFC South race.