The Detroit Lions and Buffalo Bills open their respective seasons with identical 1-0 records, meeting Thursday night at Highmark Stadium in Orchard Park, New York. The game kicks off September 17, 2026 at 8:15 PM EDT and streams on Prime Video. DraftKings lists Buffalo as a 4.5-point favorite with an over/under of 54.5 points.
Both teams enter the contest having won their season openers, setting up an early test of how each squad builds on that momentum. The Bills host the Lions in a matchup that carries added weight given the narrow spread, suggesting oddsmakers expect a competitive finish. Coverage begins with the scheduled kickoff, with no neutral-site considerations affecting travel or preparation for either team.