The Bills enter week 5 with a 3‑1 record, while the Rams sit at 2‑2 after four games. This regular‑season matchup will be played at SoFi Stadium in Inglewood, California, with the Rams listed as three‑point favorites (LAR -3) and the total set at 54.5 points. The game kicks off at 8:15 p.m. EDT on October 12, 2026, and will be carried by ESPN and ABC.
Coverage across ESPN and ABC gives the contest national exposure, and the Rams will host the Bills at their home field as both clubs look to improve their standing in week 5 of the 2026 season.