At SoFi Stadium in Inglewood, the Arizona Cardinals will take on the Los Angeles Chargers on September 13, 2026, at 4:25 p.m. EDT. Both teams enter the opener with 0‑0 records, and the game will be televised on CBS.
DraftKings has the Chargers favored by 9.5 points with a 47.5‑point over/under. With no injuries or weather updates reported, the matchup will hinge on how each offense performs in the season’s first outing.